A baby girl who was born with HIV has been cured after very early
treatment with standard drug therapy, US researchers have said, in a
potentially groundbreaking case that could help eradicate HIV infection
in its youngest victims.
Specialists made the announcement on Sunday at a major AIDS meeting in the US city of Atlanta.
"This is a proof of concept that HIV can be potentially curable in
infants," said Dr. Deborah Persaud, a virologist at Johns Hopkins
University in Baltimore, who presented the findings.
The baby girl was born in a rural hospital in the state of
Mississippi and her mother had just tested positive for HIV infection.
A team of doctors at the University of Mississippi Medical Centre in
Jackson then put the infant on a cocktail of three standard HIV-fighting
drugs when she was just 30 hours old.
That fast action apparently knocked out the HIV in the baby's blood before it could form reservoirs in the body.
The new findings could be especially critical for AIDS-plagued
African countries where many babies are born with the virus, researchers
said.
"You could call this about as close to a cure, if not a cure, that
we've seen,'' Dr. Anthony Fauci of the National Institutes of Health,
who is familiar with the findings, told The Associated Press.
'Berlin patient'
The child's story is different from the now famous case of Timothy
Ray Brown, the so-called "Berlin patient," whose HIV infection was
completely eradicated through an elaborate treatment for leukemia in
2007.
Instead of Brown's costly treatment, the Mississippi baby's case
involved the use of a cocktail of widely available drugs already used to
treat HIV infection in infants.
More testing needs to be done to see if the treatment would have the
same effect on other children, but the results could change the way
high-risk babies are treated and possibly lead to a cure for children
with HIV, the virus that causes AIDS.
Persaud's team is now planning a study to try to prove that, with more aggressive treatment of other high-risk babies.
No one should stop anti-AIDS drugs as a result of this case, Fauci
cautioned. But "it opens up a lot of doors'' to research if other
children can be helped, he said. "It makes perfect sense what
happened.''
Better than treatment is to prevent babies from being born with HIV in the first place.
About 300,000 children were born with HIV in 2011, mostly in poor
countries where only about 60 percent of infected pregnant women get
treatment that can keep them from passing the virus to their babies.
In the US, such births are very rare because HIV testing and treatment long have been part of prenatal care.
Dr. Rowena Johnston, vice president and director of research for the
Foundation for AIDS Research, which helped fund the study, said the fact
that the cure was achieved by antiretroviral therapy alone makes it
"imperative that we learn more about a newborn's immune system, how it
differs from an adult's and what factors made it possible for the child
to be cured." from aljazera
No comments:
Post a Comment